Pioneer of the chemically functionalized glucides
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[Biological properties]
Reconstructed heparin: HCPS

HCPS, heparin-carrying polystyrene, is a functionalized heparin to suppress blood coagulant activity and to enhance affinity to growth factors (GFs). J. Biochem 2000; 127:797-803









Heparin-peculiar anticoagulant activity is suppressed.

  • HCPS prolongs coagulation time than native heparin.
  • Native: naturally occurring heparin
  • LMW: low-molecular weight heparin
  • HCPS: reconstructed heparin



The reconstruction of heparin improved avidity against GFs.
J. Biochem 2000; 127:797-803

  • IC50 that means the concentrations of inhibitory heparinoid to desorb 50% of growth factors which are bound to the commercially available heparinized adsorbents were assessed.
  • It was revealed that HCPS desorbed every growth factors at even a very low concentration.
  • The avidity against GFs of HCPS is higher than that of natural heparin.

  • VEGF: Vascular endothelial growth factor
  • FGF: Fibroblast growth factor
  • HGF: Hepatocyte growth factor




HCPS strongly inhibits angiogenesis.

  • VEGF (vascular endothelial growth factor)-dependent tubular formation is an intrinsic function of human umbilical vein endothelial cell (HUVEC).
  • The application of heparin inhibits the tubular formation through the competitive binding with VEGF.
  • HCPS presented the inhibitory effect of the tubular formation even if in the low-level dosage.






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