Heparin-peculiar anticoagulant activity is suppressed.

• HCPS prolongs coagulation time than native heparin.

• 
• Native: naturally occurring heparin
• LMW: low-molecular weight heparin
• HCPS: reconstructed heparin

The reconstruction of heparin improved avidity against GFs.
J. Biochem 2000; 127:797-803

• IC50 that means the concentrations of inhibitory heparinoid to desorb 50% of growth factors which are bound to the commercially available heparinized adsorbents were assessed.
• It was revealed that HCPS desorbed every growth factors at even a very low concentration.

• The avidity against GFs of HCPS is higher than that of natural heparin.

• VEGF: Vascular endothelial growth factor
• FGF: Fibroblast growth factor
• HGF: Hepatocyte growth factor

HCPS strongly inhibits angiogenesis.

• VEGF (vascular endothelial growth factor)-dependent tubular formation is an intrinsic function of human umbilical vein endothelial cell (HUVEC).
• The application of heparin inhibits the tubular formation through the competitive binding with VEGF.
• HCPS presented the inhibitory effect of the tubular formation even if in the low-level dosage.

Antiangiogenesis